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The use of a Adrenaline Auto-injector (EpiPens®) by First Aiders

Epipen is a registered trademark of Meda Pharmaceuticals Ltd. Epipen is one of a number of pre-filled adrenaline auto-injector available in the UK. The use of this term does not signify any preference of Epipen over any other brand.

Can a first aider can administer adrenaline to a casualty who is experiencing an anaphylactic reaction?

Yes, however it is important to know why because the laws that exist to allow people to administer adrenaline via an Adrenaline Auto Injector (AAI) are specific to adrenaline and do not translate to other drugs or other medical problems.

So what are the regulations?

Laws on medicines are very strict: No one should administer any prescription medication or encourage someone to take another person’s medication:

Regulation 214(2) of the Human Medicines Regulations 2012 specifies that, for Prescription Only Medicines (POMs) no person shall administer (otherwise to himself) any such medicinal product unless he is an appropriate practitioner, or a person acting in accordance with the directions of an appropriate practitioner. (An appropriate practitioner is a doctor, a dentist, a supplementary prescriber and, within the terms of the legislation covering their prescribing, independent nurse practitioners).

In the case of Adrenalin by 'auto-injection', Regulation 238 of the 2012 Regulations provides an exemption to where "Regulation 214(2) does not apply to the administration of a prescription only medicine specified in Schedule 19 where this is for the purpose of saving life in an emergency."

Schedule 19 includes Adrenaline 1:1000 up to 1mg for intramuscular use in anaphylaxis, this is the concentration found in auto-injectors. Because of the seriousness of the situation, a casualty who has become exposed to an allergen and is displaying signs of reaction a lay-person can and should administer a casualty's adrenaline if the casualty has it with them.

This situation is accepted and reinforced by the Health & Safety Executive in their statement here.

Furthermore, the United Kingdom Resuscitation Council's statement here, states:

"There is no legal problem in any person administering adrenaline that is either prescribed for a specific person or administering adrenaline to an unknown person in such a lifesaving situation (through specific exemptions in the medicines act).

However, the first aider involved must be competent in being able to recognise the anaphylactic reaction and administer adrenaline using an auto-injector.

First aiders must ensure that they work within the guidelines of the first aid training organisation that issued their qualification and their employer."

To conclude, if you are suitably trained in the recognition of an anaphylactic reaction and the administration of an adrenaline auto-injector, it is not just permissible but recommended that the casualty is administered with that adrenaline, with or without a prescription.

Does the same apply to Asthma Inhalers or GTN spray?

No. Whilst these, and other drugs, are also included in Schedule 19, the permission of a lay person to administer Adrenaline to a casualty in the interest of saving life is only extended to Adrenaline.

Using an auto-injector


Epi-Pens are available in the following doses:

Adult (yellow): 0.3mg

Child (white): 0.15mg

Emerade® - temporary withdrawn in UK

Emerade is available in the following doses:

Large Adult ( +60kg) 0.5mg

Adult (+25kg) 0.3mg

Child ( 15-25kg) 0.15mg


Jext is available in the following doses:

Adult ( +30kg) 0.3mg

Child ( 15-30kg) 0.15mg

Needle Length

Adrenaline Auto Injectors are designed to deliver and intra-muscular injection, allowing absorption up to 4 times quicker than subcutaneous route. The nominal length of the exposed needle of Epipen and Jext auto-injectors are 15.02mm and 15.36mm respectively which has been found to be not long enough to penetrate the cutaneous layer and muscle fascia when administered in the thigh, in the majority of adult cases.

The Medicines & Healthcare Products Regulatory Agency and the UK Resuscitation Council recommend an needle length of 25mm in all adult cases.

The Emerade auto-injector has a nominal needle length of 25mm (for adult 0.5mg and 0.3mg doses) and 16mm (for infant 0.15mg doses) meaning the Emerade auto-injector more effective in the emergency administration of adrenalin for the anaphylactic casualty.

Should I carry an adrenaline auto-injector just in case?

No. Regulation 238 gives permission for a lay-person to administer Adrenaline for the purpose of saving life if it is available. To carry Adrenaline around with you, with the intention of treating a casualty you may encounter is, effectively, prescribing the drug, which is illegal.

Regulation 214(1) (not to be confused with Regulation 214(2) cited above) states:

"A person may not sell or supply a prescription only medicine except in accordance with a prescription given by an appropriate practitioner."

To carry an AAI (or other POM such as an Asthma inhaler or GTN) is intention to supply without the correct prescription for that medication.

Under Regulation 255(4) it is an offence to supply a prescription medicine

A person is guilty of an offence if—

(a) Person has in Person's possession a medicinal product to which regulation 214(1) applies; and (b) Person intends to supply it otherwise than in accordance with a prescription of an appropriate practitioner.

The use of AAI is covered on all of our first aid courses. The Practice Nurse at your GP’s surgery will also be able to train you in the use of these pens.

As with all common medical conditions (such as asthma, epilepsy and diabetes etc.) the experts are those who live with the conditions; get to know the people you work with and ask them what they would do and how they manage their condition. Work with them to develop a simple procedure should an emergency occur.

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